Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.67 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.59 |
| ▸ | CIT | O14578 | 1/20 | 0.54 |
| ▸ | GAK | O14976 | 1/20 | 0.54 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.54 |
| ▸ | STK10 | O94804 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | LYN | P07948 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | MET | P08581 | 1/20 | 0.54 |
| ▸ | HCK | P08631 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.54 |
| ▸ | AXL | P30530 | 1/20 | 0.54 |
| ▸ | CCKAR | P32238 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18633014 | 0.93 | EGFR (0.69) | EGFRERBB2GAKRIPK2LCK | |
| SCHEMBL18633148 | 0.92 | EGFR (0.71) | EGFRERBB2GAKRIPK2LCK | |
| SCHEMBL15090487 | 0.91 | EGFR (0.81) | EGFRERBB2CITGAKEPHB6 | |
| SCHEMBL255942 | 0.91 | EGFR (0.81) | EGFRERBB2CITGAKEPHB6 | |
| SCHEMBL256544 | 0.84 | EGFR (0.74) | EGFRERBB2CITGAKEPHB6 | |
| SCHEMBL15090569 | 0.84 | EGFR (0.84) | EGFRERBB2GAKRIPK2LCK | |
| SCHEMBL15090527 | 0.84 | EGFR (0.84) | EGFRERBB2GAKRIPK2LCK | |
| Hydrochloric Acid SCHEMBL15104756 | 0.84 | EGFR (0.83) | EGFRERBB2GAKRIPK2LCK | |
| Hydrochloric Acid SCHEMBL15090765 | 0.84 | EGFR (0.83) | EGFRERBB2GAKRIPK2LCK | |
| SCHEMBL15090676 | 0.84 | EGFR (0.83) | EGFRERBB2GAKRIPK2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2612860-B1 | QUINAZOLINE DERIVATIVES SUBSTITUTED BY ANILINE, PREPARATION METHOD AND USE THEREOF | XUANZHU PHARMA CO LTD (CN) | 2017-03-15 | — | — | EP | disclosed |