Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18633820 | 0.84 | CCR1 (0.37) | CCR1MCHR1 | |
| SCHEMBL18896011 | 0.83 | CCR1 (0.37) | CCR1MCHR1 | |
| SCHEMBL18895954 | 0.82 | CCR1 (0.37) | CHRM2CCR1CCR5HRH1KDM4C | |
| SCHEMBL18895955 | 0.81 | CCR1 (0.38) | CCR1 | |
| SCHEMBL15478412 | 0.80 | CCR1 (0.62) | CHRM2CCR1CCR5HRH1KDM4C | |
| SCHEMBL654715 | 0.80 | CCR1 (0.62) | CHRM2CCR1CCR5HRH1KDM4C | |
| SCHEMBL654716 | 0.80 | CCR1 (0.62) | CHRM2CCR1CCR5HRH1KDM4C | |
| SCHEMBL18895962 | 0.76 | CCR1 (0.39) | CHRM2CCR1CCR5 | |
| SCHEMBL15478400 | 0.76 | CCR1 (0.37) | CHRM2CCR1CCR5HRH1 | |
| SCHEMBL18895959 | 0.76 | CCR1 (0.34) | CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663537-B2 | Chemokine receptor antagonists and methods of use | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2017-05-30 | — | — | US | disclosed |
| EP-1688418-B1 | Chemokine receptor antagonists and methods of use thereof | MILLENNIUM PHARM INC (US) | 2017-03-15 | — | — | EP | disclosed |