Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.32 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18633833 | 0.85 | CCR1 (0.42) | CCR1HRH3SIGMAR1KCNK2USP2 | |
| SCHEMBL12121948 | 0.70 | CCR1 (0.68) | CCR1HRH3SIGMAR1KCNK2USP2 | |
| SCHEMBL16312668 | 0.69 | CCR1 (0.39) | CCR1HRH3SIGMAR1KCNK2USP2 | |
| SCHEMBL15478321 | 0.69 | CCR1 (0.43) | CCR1HRH3SIGMAR1KCNK2USP2 | |
| SCHEMBL18633827 | 0.69 | CCR1 (0.39) | CCR1HRH3SIGMAR1KCNK2USP2 | |
| SCHEMBL12936668 | 0.68 | CCR1 (0.43) | CCR1HRH3SIGMAR1KCNK2USP2 | |
| SCHEMBL14579804 | 0.65 | CCR1 (0.48) | CCR1TP53 | |
| SCHEMBL15478381 | 0.64 | CCR1 (0.38) | CCR1SIGMAR1 | |
| SCHEMBL13824458 | 0.62 | CCR1 (0.37) | CCR1HRH3HRH1 | |
| SCHEMBL15478357 | 0.61 | CCR1 (0.63) | CCR1SIGMAR1KCNK2USP2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1688418-B1 | Chemokine receptor antagonists and methods of use thereof | MILLENNIUM PHARM INC (US) | 2017-03-15 | — | — | EP | disclosed |