Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 12/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10309545 | 0.73 | PDE10A (1.00) | PDE10ACYP2C9NOS1NOS2SMN1; SMN2 | |
| SCHEMBL15038167 | 0.70 | PDE10A (0.59) | PDE10ACYP2C9NOS1NOS2SMN1; SMN2 | |
| SCHEMBL15038168 | 0.69 | PDE10A (0.54) | PDE10ACYP2C9NOS1NOS2SMN1; SMN2 | |
| SCHEMBL7458054 | 0.69 | PDE10A (0.62) | PDE10ALMNA | |
| SCHEMBL7514548 | 0.68 | PDE10A (0.61) | PDE10ACYP2C9NOS1NOS2BRD4 | |
| SCHEMBL10345170 | 0.67 | PDE10A (0.58) | PDE10ACYP2C9NOS1NOS2BRD4 | |
| SCHEMBL10309548 | 0.67 | PDE10A (0.70) | PDE10A | |
| SCHEMBL18634778 | 0.66 | PDE10A (0.47) | PDE10ACYP2C9NOS1NOS2SMN1; SMN2 | |
| SCHEMBL18634725 | 0.64 | PDE10A (0.45) | PDE10ASMN1; SMN2LMNA | |
| SCHEMBL18634584 | 0.64 | PDE10A (0.45) | PDE10ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2663565-B1 | HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC (US) | 2017-03-15 | — | — | EP | disclosed |