Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.45 |
| ▸ | TNK2 | Q07912 | 6/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | POLRMT | O00411 | 1/20 | 0.33 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25909400 | 0.94 | TMPRSS2 (0.47) | TMPRSS2TNK2PRMT5WDR77POLRMT | |
| SCHEMBL26003209 | 0.89 | TMPRSS2 (0.37) | TMPRSS2PRMT5WDR77POLRMT | |
| SCHEMBL26003158 | 0.88 | TMPRSS2 (0.50) | TMPRSS2POLRMT | |
| SCHEMBL25381965 | 0.87 | TMPRSS2 (0.47) | TMPRSS2TNK2PRMT5WDR77POLRMT | |
| SCHEMBL26004157 | 0.86 | TMPRSS2 (0.41) | TMPRSS2TNK2PRMT5WDR77POLRMT | |
| SCHEMBL20144211 | 0.85 | TMPRSS2 (0.44) | TMPRSS2TNK2PRMT5WDR77POLRMT | |
| SCHEMBL16519861 | 0.85 | TMPRSS2 (0.49) | TMPRSS2PRMT5WDR77POLRMT | |
| SCHEMBL17722662 | 0.85 | TMPRSS2 (0.45) | TMPRSS2POLRMT | |
| SCHEMBL20878443 | 0.85 | TMPRSS2 (0.45) | TMPRSS2POLRMT | |
| SCHEMBL24418860 | 0.84 | TMPRSS2 (0.46) | TMPRSS2POLRMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10695357-B2 | Methods for treating filoviridae virus infections | GILEAD SCIENCES, INC. (US) | 2020-06-30 | — | — | US | disclosed |
| US-20190275063-A1 | METHODS FOR TREATING FILOVIRIDAE VIRUS INFECTIONS | GILEAD SCIENCES, INC. | 2019-09-12 | — | — | US | disclosed |
| US-10251904-B2 | Methods for treating arenaviridae and coronaviridae virus infections | GILEAD SCIENCES, INC. (US) | 2019-04-09 | — | — | US | disclosed |
| US-9949994-B2 | Methods for treating Filoviridae virus infections | GILEAD SCIENCES, INC. (US) | 2018-04-24 | — | — | US | disclosed |
| US-20170071964-A1 | METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS | GILEAD SCIENCES, INC. | 2017-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10251904-B2 | Methods for treating arenaviridae and coronaviridae virus infections | ACE, PNP, ACE2 | TMPRSS2 12/4885TNK2 1941/4885PRMT5 3439/4885 |
| US-20190275063-A1 | METHODS FOR TREATING FILOVIRIDAE VIRUS INFECTIONS | PNP, PRPF4, RPIA | TMPRSS2 1951/4885TNK2 2705/4885PRMT5 855/4885 |
| US-10695357-B2 | Methods for treating filoviridae virus infections | PNP, PRPF4, RPIA | TMPRSS2 1951/4885TNK2 2705/4885PRMT5 855/4885 |
| US-20170071964-A1 | METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS | ACE, PNP, ACE2 | TMPRSS2 12/4885TNK2 1941/4885PRMT5 3439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.