Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 18/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12605013 | 1.00 | HRH4 (0.62) | HRH4ROCK1KCNH2HRH3HTR3A | |
| SCHEMBL18486240 | 0.90 | HRH4 (0.62) | HRH4ROCK1KCNH2HRH3HTR3A | |
| SCHEMBL5152791 | 0.90 | HRH4 (0.62) | HRH4ROCK1KCNH2HRH3HTR3A | |
| SCHEMBL18486242 | 0.90 | HRH4 (0.62) | HRH4ROCK1KCNH2HRH3HTR3A | |
| SCHEMBL1775551 | 0.84 | HRH4 (0.66) | HRH4ROCK1HTR3A | |
| SCHEMBL1775550 | 0.84 | HRH4 (0.66) | HRH4ROCK1HTR3A | |
| SCHEMBL5155514 | 0.84 | HRH4 (0.62) | HRH4ROCK1KCNH2HRH3HTR3A | |
| SCHEMBL5155504 | 0.84 | HRH4 (0.62) | HRH4ROCK1KCNH2HRH3HTR3A | |
| SCHEMBL1774896 | 0.84 | HRH4 (0.60) | HRH4HRH3HTR3A | |
| SCHEMBL18636736 | 0.81 | HRH4 (0.67) | HRH4ROCK1HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966162-B1 | PYRIMIDINE DERIVATIVES | ZIARCO PHARMA LTD (GB) | 2017-03-15 | — | — | EP | disclosed |