Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 16/20 | 0.78 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1774498 | 0.90 | HRH4 (0.68) | HRH4HRH3KCNH2 | |
| SCHEMBL4754217 | 0.90 | HRH4 (0.74) | HRH4HRH3KCNH2HRH2NUDT1 | |
| SCHEMBL4754214 | 0.90 | HRH4 (0.74) | HRH4HRH3KCNH2HRH2NUDT1 | |
| SCHEMBL12605057 | 0.88 | HRH4 (1.00) | HRH4HRH3KCNH2 | |
| SCHEMBL18636731 | 0.87 | HRH4 (0.60) | HRH4HRH3KCNH2 | |
| SCHEMBL1774659 | 0.87 | HRH4 (0.77) | HRH4HRH3KCNH2NUDT1 | |
| SCHEMBL5153086 | 0.86 | HRH4 (0.73) | HRH4HRH3KCNH2HRH2 | |
| SCHEMBL1775620 | 0.85 | HRH3 (0.59) | HRH4HRH3KCNH2NUDT1 | |
| SCHEMBL1773378 | 0.82 | HRH3 (0.62) | HRH4HRH3KCNH2NUDT1 | |
| SCHEMBL12605080 | 0.82 | HRH4 (0.73) | HRH4HRH3HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966162-B1 | PYRIMIDINE DERIVATIVES | ZIARCO PHARMA LTD (GB) | 2017-03-15 | — | — | EP | disclosed |