SCHEMBL18636739

SCHEMBL18636739

CC[C@@H](C)Nc1cc(N2CCN(C)C2)nc(N)n1

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 16/20 0.64
HRH3 Q9Y5N1 4/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18636724 0.80 HRH4 (0.50) HRH4HRH3
SCHEMBL12605090 0.79 HRH4 (1.00) HRH4HRH3
SCHEMBL1773675 0.78 HRH4 (0.63) HRH4HRH3
SCHEMBL1775039 0.78 HRH4 (0.63) HRH4HRH3
SCHEMBL18636774 0.76 HRH4 (0.56) HRH4HRH3
SCHEMBL1774993 0.76 HRH4 (0.79) HRH4HRH3
SCHEMBL1774451 0.76 HRH4 (0.79) HRH4HRH3
SCHEMBL18636738 0.76 HRH4 (0.79) HRH4HRH3
SCHEMBL25493609 0.75 HRH4 (0.54) HRH4
SCHEMBL20170642 0.75 HRH4 (0.64) HRH4HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1966162-B1 PYRIMIDINE DERIVATIVES ZIARCO PHARMA LTD (GB) 2017-03-15 EP disclosed