Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 16/20 | 0.80 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12605054 | 0.89 | HRH4 (1.00) | HRH4HRH3PIK3CB | |
| SCHEMBL1775492 | 0.88 | HRH4 (0.76) | HRH4HRH3PIK3CB | |
| SCHEMBL1775493 | 0.88 | HRH4 (0.76) | HRH4HRH3PIK3CB | |
| SCHEMBL12605070 | 0.84 | HRH4 (0.78) | HRH4HRH3 | |
| SCHEMBL1775730 | 0.84 | HRH4 (0.67) | HRH4HRH3PIK3CBSMN1; SMN2APP | |
| SCHEMBL1775731 | 0.84 | HRH4 (0.69) | HRH4HRH3PIK3CBSMN1; SMN2APP | |
| SCHEMBL18636771 | 0.83 | HRH4 (0.60) | HRH4HRH3PIK3CBAPP | |
| SCHEMBL12604981 | 0.79 | HRH4 (0.63) | HRH4HRH3PIK3CB | |
| SCHEMBL1774786 | 0.76 | HRH4 (0.79) | HRH4HRH3PIK3CB | |
| SCHEMBL5153294 | 0.76 | HRH4 (0.57) | HRH4SMN1; SMN2APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966162-B1 | PYRIMIDINE DERIVATIVES | ZIARCO PHARMA LTD (GB) | 2017-03-15 | — | — | EP | disclosed |