Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.45 |
| ▸ | GSK3A | P49840 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 9/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.38 |
| ▸ | CDK2 | P24941 | 8/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 8/20 | 0.38 |
| ▸ | JUN | P05412 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15298151 | 0.81 | CDK2 (0.53) | MAPK8MAPK10MAPK9MAPK14CCND1 | |
| SCHEMBL18638033 | 0.81 | CDK2 (0.53) | MAPK8MAPK10MAPK9MAPK14CCND1 | |
| SCHEMBL20792918 | 0.77 | MAPK8 (0.45) | MAPK8MAPK10MAPK9GSK3AGSK3B | |
| SCHEMBL17539998 | 0.74 | MAPK8 (0.49) | MAPK8MAPK10MAPK9GSK3AGSK3B | |
| SCHEMBL20387853 | 0.72 | CDK2 (0.68) | CCND1CCNE1CDK2CDK6CDK4 | |
| SCHEMBL18638036 | 0.71 | CDK2 (0.56) | CCND1CCNE1CDK2CDK6CDK4 | |
| SCHEMBL15298252 | 0.71 | CDK2 (0.56) | CCND1CCNE1CDK2CDK6CDK4 | |
| SCHEMBL18637773 | 0.70 | CDK2 (0.55) | CCND1CCNE1CDK2CDK6CDK4 | |
| SCHEMBL22570125 | 0.69 | KDM4E (0.40) | CCND1CCNE1CDK2CDK6CDK4 | |
| SCHEMBL3305259 | 0.68 | MAPK14 (0.62) | MAPK8MAPK10MAPK9MAPK14CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2831080-B1 | LACTAM KINASE INHIBITORS | TAVARES FRANCIS XAVIER (US) | 2017-03-15 | — | — | EP | disclosed |