Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.66 |
| ▸ | JAK1 | P23458 | 10/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.66 |
| ▸ | JAK3 | P52333 | 5/20 | 0.66 |
| ▸ | TYK2 | P29597 | 4/20 | 0.66 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.66 |
| ▸ | PAK4 | O96013 | 2/20 | 0.66 |
| ▸ | ABL1 | P00519 | 2/20 | 0.66 |
| ▸ | RET | P07949 | 2/20 | 0.66 |
| ▸ | LTK | P29376 | 2/20 | 0.66 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.66 |
| ▸ | CLK2 | P49760 | 2/20 | 0.66 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.66 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.66 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.66 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.66 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.66 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.66 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.66 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24767577 | 0.95 | JAK2 (0.68) | JAK2JAK1HDAC6JAK3TYK2 | |
| SCHEMBL102212 | 0.89 | JAK2 (0.70) | JAK2JAK1HDAC6JAK3TYK2 | |
| SCHEMBL19592337 | 0.87 | JAK2 (0.70) | JAK2JAK1HDAC6JAK3TYK2 | |
| SCHEMBL24767657 | 0.87 | JAK2 (0.70) | JAK2JAK1HDAC6JAK3TYK2 | |
| SCHEMBL24767659 | 0.86 | JAK2 (0.72) | JAK2JAK1HDAC6JAK3TYK2 | |
| SCHEMBL18896326 | 0.85 | JAK2 (0.70) | JAK2JAK1HDAC6JAK3TYK2 | |
| SCHEMBL18896333 | 0.85 | JAK2 (0.70) | JAK2JAK1HDAC6JAK3TYK2 | |
| SCHEMBL100350 | 0.85 | JAK2 (0.65) | JAK2JAK1HDAC6JAK3TYK2 | |
| SCHEMBL101797 | 0.85 | JAK2 (0.73) | JAK2JAK1HDAC6JAK3TYK2 | |
| SCHEMBL24053685 | 0.85 | JAK2 (0.75) | JAK2JAK1HDAC6JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11331320-B2 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2022-05-17 | — | — | US | disclosed |
| US-20200338077-A1 | HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION | 2020-10-29 | — | — | US | disclosed |
| US-9974790-B2 | Heteroaryl substituted pyrrolo[2,3-B] pyridines and pyrrolo[2,3-B] pyrimidines as janus kinase inhibitors | INCYTE CORPORATION (US) | 2018-05-22 | — | — | US | disclosed |
| US-9814722-B2 | Heteroaryl substituted pyrrolo[2,3-B] pyridines and pyrrolo[2,3-B] pyrimidines as janus kinase inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2017-11-14 | — | — | US | disclosed |
| US-20170071947-A1 | Heteroaryl Substituted Pyrrolo[2,3-B] Pyridines And Pyrrolo[2,3-B] Pyrimidines As Janus Kinase Inhibitors | INCYTE CORPORATION | 2017-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170071947-A1 | Heteroaryl Substituted Pyrrolo[2,3-B] Pyridines And Pyrrolo[2,3-B] Pyrimidines As Janus Kinase Inhibitors | JAK3, JAK1, JAK2 | JAK2 3/4885JAK1 2/4885HDAC6 2492/4885 |
| US-20200338077-A1 | HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS | JAK3, JAK1, JAK2 | JAK2 3/4885JAK1 2/4885HDAC6 2492/4885 |
| US-11331320-B2 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | JAK3, JAK1, JAK2 | JAK2 3/4885JAK1 2/4885HDAC6 2492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.