Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26076127 | 0.87 | CYP1A2 (0.39) | POLBCYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL18856538 | 0.87 | CYP1A2 (0.39) | POLBCYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL19134507 | 0.86 | CYP1A2 (0.38) | POLBCYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL20320538 | 0.85 | POLB (0.38) | POLBCYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL20320523 | 0.84 | POLB (0.36) | POLBCYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL14530597 | 0.76 | POLB (0.36) | POLBCYP1A2CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL171117 | 0.74 | KMT2A (0.48) | POLBHCAR2MEN1KMT2AALDH1A1 | |
| SCHEMBL20320359 | 0.74 | TP53 (0.31) | POLBRORCTP53 | |
| SCHEMBL18948838 | 0.72 | — | — | |
| SCHEMBL18483392 | 0.72 | HCAR2 (0.32) | POLBHCAR2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440550-B1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | UNIV LEUVEN KATH (BE) | 2017-03-15 | — | — | EP | disclosed |