Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 18/20 | 0.86 |
| ▸ | EGFR | P00533 | 2/20 | 0.86 |
| ▸ | TEC | P42680 | 2/20 | 0.86 |
| ▸ | CD69 | Q07108 | 1/20 | 0.86 |
| ▸ | LYN | P07948 | 2/20 | 0.66 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.66 |
| ▸ | LCK | P06239 | 1/20 | 0.66 |
| ▸ | FYN | P06241 | 1/20 | 0.66 |
| ▸ | YES1 | P07947 | 1/20 | 0.66 |
| ▸ | HCK | P08631 | 1/20 | 0.66 |
| ▸ | SRC | P12931 | 1/20 | 0.66 |
| ▸ | CSK | P41240 | 1/20 | 0.66 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.66 |
| ▸ | BLK | P51451 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26541434 | 0.98 | BTK (0.82) | BTKEGFRTECCD69LYN | |
| SCHEMBL18645217 | 0.96 | BTK (0.79) | BTKEGFRTECCD69LYN | |
| SCHEMBL18644879 | 0.94 | BTK (0.89) | BTKEGFRTECCD69LYN | |
| Tolebrutinib SCHEMBL18285624 | 0.93 | BTK (1.00) | BTKEGFRTECCD69LYN | |
| Tolebrutinib SCHEMBL29564612 | 0.93 | BTK (1.00) | BTKEGFRTECCD69LYN | |
| Tolebrutinib SCHEMBL18285621 | 0.93 | BTK (1.00) | BTKEGFRTECCD69LYN | |
| Tolebrutinib SCHEMBL29999020 | 0.93 | BTK (1.00) | BTKEGFRTECCD69LYN | |
| SCHEMBL18644867 | 0.93 | BTK (0.88) | BTKEGFRTECCD69LYN | |
| SCHEMBL18644873 | 0.93 | BTK (0.88) | BTKEGFRTECCD69LYN | |
| SCHEMBL18644838 | 0.92 | BTK (0.73) | BTKEGFRTECCD69LYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017041536-A1 | OXO-DIHYDROIMIDAZO PYRIDINE COMPOUND AND APPLICATIONS THEREOF | 东莞市真兴贝特医药技术有限公司 | 2017-03-16 | — | — | WO | disclosed |