Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.75 |
| ▸ | EGFR | P00533 | 2/20 | 0.75 |
| ▸ | TEC | P42680 | 2/20 | 0.75 |
| ▸ | CD69 | Q07108 | 1/20 | 0.75 |
| ▸ | LCK | P06239 | 2/20 | 0.61 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.61 |
| ▸ | FYN | P06241 | 1/20 | 0.61 |
| ▸ | YES1 | P07947 | 1/20 | 0.61 |
| ▸ | LYN | P07948 | 1/20 | 0.61 |
| ▸ | HCK | P08631 | 1/20 | 0.61 |
| ▸ | SRC | P12931 | 1/20 | 0.61 |
| ▸ | CSK | P41240 | 1/20 | 0.61 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28076724 | 0.91 | BTK (0.62) | BTKEGFRTECCD69 | |
| SCHEMBL18645216 | 0.91 | BTK (0.67) | BTKEGFRTECCD69LCK | |
| SCHEMBL18285514 | 0.87 | BTK (0.70) | BTKEGFRTECCD69LCK | |
| SCHEMBL18285511 | 0.87 | BTK (0.70) | BTKEGFRTECCD69LCK | |
| Tolebrutinib SCHEMBL29999020 | 0.86 | BTK (1.00) | BTKEGFRTECCD69LCK | |
| Tolebrutinib SCHEMBL18285621 | 0.86 | BTK (1.00) | BTKEGFRTECCD69LCK | |
| Tolebrutinib SCHEMBL18285624 | 0.86 | BTK (1.00) | BTKEGFRTECCD69LCK | |
| Tolebrutinib SCHEMBL29564612 | 0.86 | BTK (1.00) | BTKEGFRTECCD69LCK | |
| SCHEMBL18644879 | 0.80 | BTK (0.89) | BTKEGFRTECCD69LCK | |
| SCHEMBL18644868 | 0.80 | BTK (0.85) | BTKEGFRTECCD69LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017041536-A1 | OXO-DIHYDROIMIDAZO PYRIDINE COMPOUND AND APPLICATIONS THEREOF | 东莞市真兴贝特医药技术有限公司 | 2017-03-16 | — | — | WO | disclosed |