Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 5/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | HTR1F | P30939 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5387687 | 0.86 | SLC6A4 (0.59) | SLC6A4HTR1AHTR2AFFAR1GPR84 | |
| SCHEMBL6638279 | 0.83 | SLC6A4 (0.56) | SLC6A4HTR1AHTR2AFFAR1GPR84 | |
| SCHEMBL27779713 | 0.82 | SLC6A4 (0.59) | SLC6A4HTR1AHTR2AFFAR1GPR84 | |
| SCHEMBL30877225 | 0.81 | SLC6A4 (0.54) | SLC6A4HTR1AHTR2AHTR2CHTR1F | |
| SCHEMBL30711563 | 0.79 | SLC6A4 (0.55) | SLC6A4HTR1AHTR2AFFAR1GPR84 | |
| SCHEMBL6640448 | 0.79 | SLC6A4 (0.52) | SLC6A4HTR1AHTR2AFFAR1GPR84 | |
| SCHEMBL6087284 | 0.78 | SLC6A4 (0.54) | SLC6A4HTR1AHTR2AFFAR1GPR84 | |
| SCHEMBL8878576 | 0.78 | SLC6A4 (0.55) | SLC6A4HTR1AHTR2AADRA1D | |
| SCHEMBL30877223 | 0.77 | KDM4E (0.63) | SLC6A4HTR1AHTR2AHTR1F | |
| SCHEMBL3228171 | 0.77 | SLC6A4 (0.47) | SLC6A4HTR1AHTR2AFFAR1GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2017042643-A1 | FLUOROINDOLE DERIVATIVES AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | SUVEN LIFE SCIENCES LIMITED (IN) | 2017-03-16 | — | — | WO | disclosed |