Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.52 |
| ▸ | BTK | Q06187 | 17/20 | 0.48 |
| ▸ | BLK | P51451 | 3/20 | 0.48 |
| ▸ | LCK | P06239 | 3/20 | 0.48 |
| ▸ | LYN | P07948 | 3/20 | 0.48 |
| ▸ | FYN | P06241 | 3/20 | 0.48 |
| ▸ | TEC | P42680 | 3/20 | 0.48 |
| ▸ | BMX | P51813 | 3/20 | 0.48 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.48 |
| ▸ | YES1 | P07947 | 2/20 | 0.48 |
| ▸ | HCK | P08631 | 2/20 | 0.48 |
| ▸ | FGR | P09769 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | FER | P16591 | 2/20 | 0.48 |
| ▸ | CSK | P41240 | 2/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | ITK | Q08881 | 2/20 | 0.48 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.48 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18646642 | 0.86 | BTK (0.65) | EGFRBTKBLKLCKLYN | |
| SCHEMBL18647206 | 0.85 | BTK (0.55) | EGFRBTKLCKLYNFYN | |
| SCHEMBL18647205 | 0.81 | RET (0.50) | EGFRBTKBLKLCKLYN | |
| SCHEMBL28374156 | 0.76 | EGFR (0.63) | EGFRBTKBLKLCKLYN | |
| SCHEMBL19635203 | 0.76 | EGFR (0.63) | EGFRBTKBLKLCKLYN | |
| SCHEMBL19635200 | 0.76 | EGFR (0.63) | EGFRBTKBLKLCKLYN | |
| SCHEMBL19635229 | 0.76 | EGFR (0.63) | EGFRBTKBLKLCKLYN | |
| SCHEMBL19635664 | 0.76 | EGFR (0.62) | EGFRBTKBLKLCKLYN | |
| SCHEMBL19635665 | 0.76 | EGFR (0.62) | EGFRBTKBLKLCKLYN | |
| SCHEMBL19635808 | 0.75 | BTK (0.67) | EGFRBTKBMXSRCJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017041180-A1 | HETEROCYCLIC TEC-FAMILY KINASE INHIBITORS | PHARMASCIENCE INC. (CA) | 2017-03-16 | — | — | WO | disclosed |