⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6272525 | 0.88 | CA12 (0.39) | — | |
| SCHEMBL13618850 | 0.84 | S1PR2 (0.36) | — | |
| SCHEMBL12853831 | 0.80 | — | — | |
| SCHEMBL129815 | 0.78 | — | — | |
| SCHEMBL17346405 | 0.78 | CA12 (0.61) | — | |
| SCHEMBL17346297 | 0.77 | CYP2C9 (0.31) | — | |
| SCHEMBL23065527 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL22771623 | 0.75 | — | — | |
| SCHEMBL5715864 | 0.75 | CA12 (0.53) | — | |
| Ammonia Solution, Strong SCHEMBL9405419 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230339902-A1 | TRICYCLIC LIGANDS FOR DEGRADATION OF IKZF2 OR IKZF4 | C4 THERAPEUTICS, INC. (US) | 2023-10-26 | — | — | US | disclosed |
| US-20230339902-A1 | TRICYCLIC LIGANDS FOR DEGRADATION OF IKZF2 OR IKZF4 | C4 THERAPEUTICS, INC. (US) | 2023-10-26 | — | — | US | disclosed |
| US-9598396-B2 | Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as PARP and tubulin polymerization inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-21 | — | — | US | disclosed |