SCHEMBL18650331

SCHEMBL18650331

Cc1c(Br)c(=O)n(C2CCCC2)c2nc(Nc3ccc(N4CC(O)(O)N(C(=O)OC(C)(C)C)C(O)(O)C4)cn3)ncc12

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 20/20 0.68
CCND1 P24385 19/20 0.68
CCND2 P30279 16/20 0.68
CCND3 P30281 16/20 0.68
CDK6 Q00534 2/20 0.56
CDK2 P24941 2/20 0.56
CHEK1 O14757 1/20 0.56
DAPK3 O43293 1/20 0.56
CCNT1 O60563 1/20 0.56
CCNT2 O60583 1/20 0.56
ROCK2 O75116 1/20 0.56
STK16 O75716 1/20 0.56
CCNK O75909 1/20 0.56
PDE5A O76074 1/20 0.56
PRKD3 O94806 1/20 0.56
CCNB2 O95067 1/20 0.56
ABCB11 O95342 1/20 0.56
MAP4K4 O95819 1/20 0.56
PAK4 O96013 1/20 0.56
CCNE2 O96020 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29615455 0.89 CDK4 (0.75) CDK4CCND1CCND2CCND3CDK6
SCHEMBL2074567 0.89 CDK4 (0.75) CDK4CCND1CCND2CCND3CDK6
SCHEMBL4828673 0.88 CDK4 (0.71) CDK4CCND1CCND2CCND3CDK6
SCHEMBL4825311 0.87 CDK4 (0.68) CDK4CCND1CCND2CCND3CDK6
SCHEMBL4835778 0.84 CDK4 (0.71) CDK4CCND1CCND2CCND3CDK6
SCHEMBL6223909 0.84 CDK4 (0.69) CDK4CCND1CCND2CCND3CDK6
SCHEMBL6225583 0.83 CDK4 (0.66) CDK4CCND1CCND2CCND3CDK6
SCHEMBL27667901 0.83 CDK4 (0.75) CDK4CCND1CCND2CCND3CDK6
SCHEMBL4830656 0.83 CDK4 (0.88) CDK4CCND1CCND2CCND3CDK6
SCHEMBL29507441 0.83 CDK4 (0.88) CDK4CCND1CCND2CCND3CDK6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017045648-A1 PREPARATION METHOD FOR DEUTERATED COMPOUND 正大天晴药业集团股份有限公司 2017-03-23 WO disclosed