Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24804424 | 0.73 | KDM4E (0.50) | MEN1KMT2AKDM4EL3MBTL1NPSR1 | |
| SCHEMBL15564864 | 0.73 | MEN1 (0.42) | MEN1KMT2AKDM4EL3MBTL1NPSR1 | |
| SCHEMBL1571397 | 0.71 | MEN1 (0.44) | MEN1KMT2AKDM4EL3MBTL1NPSR1 | |
| SCHEMBL15565637 | 0.68 | CYP2A6 (0.40) | MEN1KMT2AKDM4EL3MBTL1TDP1 | |
| SCHEMBL31083305 | 0.67 | BACE1 (0.43) | MEN1KMT2AKDM4EL3MBTL1NPSR1 | |
| SCHEMBL31235431 | 0.67 | HASPIN (0.42) | MEN1KMT2AKDM4EL3MBTL1SMN1; SMN2 | |
| SCHEMBL26708748 | 0.67 | KMT2A (0.42) | MEN1KMT2AKDM4ESMN1; SMN2RPS6KA5 | |
| SCHEMBL31235160 | 0.67 | KMT2A (0.42) | MEN1KMT2AKDM4ESMN1; SMN2RPS6KA5 | |
| SCHEMBL24558656 | 0.66 | MEN1 (0.45) | MEN1KMT2AKDM4EL3MBTL1NPSR1 | |
| SCHEMBL1571643 | 0.65 | MEN1 (0.35) | MEN1KMT2AKDM4EL3MBTL1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079988-A9 | QUINAZOLINES FOR PDK1 INHIBITION | NOVARTIS AG (CH) | 2011-05-12 | — | — | WO | disclosed |