Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.58 |
| ▸ | JAK2 | O60674 | 4/20 | 0.37 |
| ▸ | JAK3 | P52333 | 3/20 | 0.36 |
| ▸ | TYK2 | P29597 | 2/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.36 |
| ▸ | CDK9 | P50750 | 2/20 | 0.36 |
| ▸ | PLK1 | P53350 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | BCR | P11274 | 2/20 | 0.35 |
| ▸ | SMG1 | Q96Q15 | 2/20 | 0.35 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MARK3 | P27448 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18627953 | 0.91 | SYK (0.61) | SYKJAK2JAK3TYK2CCNT1 | |
| SCHEMBL18627906 | 0.88 | SYK (0.57) | SYKJAK2JAK3TYK2CCNT1 | |
| SCHEMBL18627938 | 0.88 | SYK (0.57) | SYKJAK2JAK3TYK2CCNT1 | |
| SCHEMBL18627929 | 0.88 | SYK (0.57) | SYKJAK2TYK2CCNT1CDK9 | |
| SCHEMBL18627898 | 0.88 | SYK (0.56) | SYKJAK2SMG1CAMK2DCDK1 | |
| SCHEMBL18627945 | 0.88 | SYK (0.56) | SYK | |
| SCHEMBL18627897 | 0.88 | SYK (0.56) | SYKJAK2JAK3TYK2CCNT1 | |
| SCHEMBL18627934 | 0.88 | SYK (0.56) | SYKJAK2JAK3TYK2CCNT1 | |
| SCHEMBL18627911 | 0.86 | SYK (0.58) | SYKJAK2JAK3TYK2CCNT1 | |
| SCHEMBL18627907 | 0.86 | SYK (0.54) | SYKJAK2JAK3CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017046302-A1 | NOVEL OXAZOLE DERIVATIVES THAT INHIBIT SYK | AB SCIENCE (FR) | 2017-03-23 | — | — | WO | disclosed |