Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14897434 | 0.81 | AAK1 (0.39) | HRH4HRH3MCHR1AAK1P2RX7 | |
| SCHEMBL20356798 | 0.81 | AAK1 (0.39) | HRH4HRH3MCHR1AAK1P2RX7 | |
| SCHEMBL14897439 | 0.74 | IRAK4 (0.47) | HRH4HRH3MCHR1AAK1 | |
| SCHEMBL14896928 | 0.70 | GRM5 (0.41) | — | |
| SCHEMBL14897164 | 0.68 | MCHR1 (0.40) | HRH4HRH3MAP4K4MCHR1AAK1 | |
| SCHEMBL14897431 | 0.68 | ATR (0.38) | HRH4HRH3MCHR1AAK1 | |
| SCHEMBL14897567 | 0.67 | HRH4 (0.43) | HRH4HRH3MAP4K4MCHR1MAPK8 | |
| SCHEMBL14896977 | 0.67 | AAK1 (0.40) | HRH4HRH3MCHR1MAPK8MAPK10 | |
| SCHEMBL3121524 | 0.66 | CSNK1E (0.69) | ENPP2 | |
| SCHEMBL16193121 | 0.66 | MCHR1 (0.38) | HRH4HRH3MAP4K4MCHR1MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |