Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 18/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654801 | 0.87 | PIM1 (0.41) | PIM1NTRK1IRAK4 | |
| SCHEMBL18654799 | 0.84 | PIM1 (0.40) | PIM1NTRK1IRAK4 | |
| SCHEMBL18654877 | 0.80 | PIM1 (0.36) | PIM1NTRK1IRAK4 | |
| SCHEMBL14896871 | 0.80 | IRAK4 (0.51) | NTRK1IRAK4 | |
| SCHEMBL18654754 | 0.79 | NTRK1 (0.38) | NTRK1IRAK4 | |
| SCHEMBL14897783 | 0.74 | IRAK4 (0.50) | NTRK1IRAK4 | |
| SCHEMBL14881882 | 0.73 | IRAK4 (0.49) | PIM1NTRK1IRAK4 | |
| SCHEMBL14897701 | 0.70 | IRAK4 (0.49) | NTRK1IRAK4 | |
| SCHEMBL14881846 | 0.70 | IRAK4 (0.50) | PIM1NTRK1IRAK4 | |
| SCHEMBL18655322 | 0.69 | GSK3B (0.38) | NTRK1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |