Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 8/20 | 0.46 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 4/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.37 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.37 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18655207 | 0.85 | IRAK4 (0.41) | IRAK4NTRK1NTRK3NTRK2 | |
| SCHEMBL18654751 | 0.85 | IRAK4 (0.41) | IRAK4NTRK1NTRK3NTRK2 | |
| SCHEMBL18654752 | 0.85 | IRAK4 (0.41) | IRAK4NTRK1NTRK3KIF18ANTRK2 | |
| SCHEMBL16193126 | 0.82 | IRAK4 (0.48) | IRAK4PIM1NTRK1EIF2AK4KIF18A | |
| SCHEMBL14896727 | 0.80 | IRAK4 (0.49) | IRAK4PIM1NTRK1NTRK3EIF2AK4 | |
| SCHEMBL16193128 | 0.80 | IRAK4 (0.49) | IRAK4PIM1NTRK1NTRK3EIF2AK4 | |
| SCHEMBL14897701 | 0.79 | IRAK4 (0.49) | IRAK4NTRK1 | |
| SCHEMBL14896897 | 0.79 | IRAK4 (0.48) | IRAK4NTRK1NTRK3NTRK2 | |
| SCHEMBL20355596 | 0.78 | IRAK4 (0.53) | IRAK4PIM1NTRK1NTRK3NTRK2 | |
| SCHEMBL14896942 | 0.77 | IRAK4 (0.49) | IRAK4PIM1NTRK1NTRK3EIF2AK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |