Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 11/20 | 0.44 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14897783 | 0.92 | IRAK4 (0.50) | IRAK4NTRK1 | |
| SCHEMBL14897492 | 0.90 | IRAK4 (0.47) | IRAK4NTRK1NTRK3 | |
| SCHEMBL14897369 | 0.89 | IRAK4 (0.49) | IRAK4NTRK1 | |
| SCHEMBL14896871 | 0.88 | IRAK4 (0.51) | IRAK4NTRK1 | |
| SCHEMBL14897275 | 0.86 | IRAK4 (0.47) | IRAK4NTRK1 | |
| SCHEMBL14897439 | 0.86 | IRAK4 (0.47) | IRAK4NTRK1NTRK3 | |
| SCHEMBL14897258 | 0.85 | IRAK4 (0.48) | IRAK4NTRK1PIM1 | |
| SCHEMBL14897701 | 0.84 | IRAK4 (0.49) | IRAK4NTRK1 | |
| SCHEMBL14896946 | 0.82 | IRAK4 (0.51) | IRAK4NTRK1 | |
| SCHEMBL14897199 | 0.82 | IRAK4 (0.49) | IRAK4NTRK1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |