Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654645 | 0.84 | SCN9A (0.35) | ABL1SCN9ASCN10AHCRTR1HCRTR2 | |
| SCHEMBL18654680 | 0.81 | SCN9A (0.36) | ABL1SCN9ASCN10AHCRTR1HCRTR2 | |
| SCHEMBL14897033 | 0.81 | ATR (0.39) | ABL1SCN9ASCN10ASCN5ASCN2A | |
| SCHEMBL14897344 | 0.81 | KIT (0.39) | ABL1SCN9ASCN10ASCN5ASCN2A | |
| SCHEMBL14897240 | 0.81 | SCN10A (0.41) | ABL1SCN9ASCN10ASCN5ASCN2A | |
| SCHEMBL14896856 | 0.81 | SCN10A (0.43) | ABL1SCN9ASCN10ASCN5ASCN2A | |
| SCHEMBL18655237 | 0.81 | ABL1 (0.36) | ABL1SCN9ASCN10AHCRTR1HCRTR2 | |
| SCHEMBL14896848 | 0.80 | SCN10A (0.40) | ABL1SCN9ASCN10ASCN5ASCN2A | |
| SCHEMBL14897243 | 0.80 | NPC1 (0.45) | SCN9ASCN10ASCN5ASCN2ASCN3A | |
| SCHEMBL14897598 | 0.80 | MPL (0.42) | ABL1SCN9ASCN10AHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |