Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.82 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.69 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11967362 | 0.93 | PIK3CA (0.82) | PIK3CAPIK3CGPIK3CD | |
| SCHEMBL11967364 | 0.90 | PIK3CA (0.86) | PIK3CAPIK3CGPIK3CD | |
| SCHEMBL11967355 | 0.90 | PIK3CA (1.00) | PIK3CAPIK3CGPIK3CD | |
| SCHEMBL16116787 | 0.90 | PIK3CA (0.80) | PIK3CAPIK3CGPIK3CD | |
| SCHEMBL1485262 | 0.89 | PIK3CA (0.80) | PIK3CAPIK3CGPIK3CD | |
| SCHEMBL1485646 | 0.87 | PIK3CA (0.81) | PIK3CAPIK3CGPIK3CD | |
| SCHEMBL1528063 | 0.85 | PIK3CA (0.77) | PIK3CAPIK3CGPIK3CD | |
| SCHEMBL11967340 | 0.84 | PIK3CA (0.75) | PIK3CAPIK3CGPIK3CD | |
| SCHEMBL11967323 | 0.83 | PIK3CD (0.73) | PIK3CAPIK3CGPIK3CD | |
| SCHEMBL1485165 | 0.82 | PIK3CA (0.71) | PIK3CAPIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170081341-A1 | BENZOXAZEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2017-03-23 | — | — | US | disclosed |
| US-20170081341-A1 | BENZOXAZEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2017-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170081341-A1 | BENZOXAZEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | BMX, PIK3CA, PI4KA | PIK3CA 2/4885PIK3CG 23/4885PIK3CD 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.