Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 2/20 | 0.43 |
| ▸ | BRAF | P15056 | 8/20 | 0.41 |
| ▸ | STS | P08842 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1868866 | 0.94 | BRAF (0.47) | NR1I2BRAFTGFBR1JAK2ERN1 | |
| SCHEMBL1866857 | 0.93 | BRAF (0.44) | NR1I2BRAFSTS | |
| SCHEMBL1865837 | 0.90 | NR1I2 (0.41) | NR1I2BRAFKCNH2EGFRERN1 | |
| SCHEMBL1872245 | 0.88 | KCNH2 (0.44) | NR1I2BRAFKCNH2EGFR | |
| SCHEMBL31111523 | 0.87 | NR1I2 (0.51) | NR1I2BRAFTGFBR1JAK2ERN1 | |
| SCHEMBL1872193 | 0.87 | NR1I2 (0.51) | NR1I2BRAFTGFBR1JAK2ERN1 | |
| SCHEMBL1870510 | 0.87 | BRAF (0.47) | NR1I2BRAFTGFBR1JAK2ERN1 | |
| SCHEMBL1868868 | 0.85 | BRAF (0.44) | NR1I2BRAFTGFBR1JAK2ERN1 | |
| SCHEMBL12669056 | 0.85 | BRAF (0.43) | NR1I2BRAFKCNH2 | |
| SCHEMBL31111990 | 0.84 | NR1I2 (0.48) | NR1I2BRAFSTSTGFBR1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498608-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011059610-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-19 | — | — | WO | disclosed |
| WO-2011059610-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-19 | — | — | WO | disclosed |