Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 4/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | CDC25B | P30305 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL265557 | 0.84 | SMN1; SMN2 (0.45) | SMN1; SMN2MEN1KMT2APOLBBRD4 | |
| SCHEMBL6736700 | 0.83 | POLB (0.46) | SMN1; SMN2MEN1KMT2APOLBBRD4 | |
| SCHEMBL15777072 | 0.82 | SMN1; SMN2 (0.41) | SMN1; SMN2MEN1KMT2APOLBF10 | |
| SCHEMBL17192238 | 0.81 | SMN1; SMN2 (0.39) | SMN1; SMN2MEN1KMT2APOLBF10 | |
| SCHEMBL2289941 | 0.81 | — | — | |
| SCHEMBL60903 | 0.79 | BRD4 (0.41) | SMN1; SMN2MEN1KMT2APOLBBRD4 | |
| SCHEMBL25299400 | 0.79 | ATM (0.39) | SMN1; SMN2MEN1KMT2APOLBBRD4 | |
| SCHEMBL19381503 | 0.78 | SMN1; SMN2 (0.39) | SMN1; SMN2MEN1KMT2APOLBF10 | |
| SCHEMBL16541489 | 0.78 | BRD4 (0.41) | SMN1; SMN2MEN1KMT2APOLBBRD4 | |
| SCHEMBL2287208 | 0.78 | BRD4 (0.41) | SMN1; SMN2MEN1KMT2APOLBBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928885-B1 | MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR-GAMMA) FOR USE IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2017-03-22 | — | — | EP | disclosed |