Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 20/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18658682 | 0.89 | LRRK2 (0.64) | LRRK2 | |
| SCHEMBL18658956 | 0.88 | LRRK2 (0.68) | LRRK2 | |
| SCHEMBL18658929 | 0.86 | LRRK2 (0.60) | LRRK2 | |
| SCHEMBL26802804 | 0.83 | LRRK2 (0.75) | LRRK2 | |
| SCHEMBL26660481 | 0.82 | LRRK2 (0.73) | LRRK2 | |
| SCHEMBL26803565 | 0.82 | LRRK2 (0.73) | LRRK2 | |
| SCHEMBL18634666 | 0.82 | LRRK2 (0.73) | LRRK2 | |
| SCHEMBL26805531 | 0.82 | LRRK2 (0.73) | LRRK2 | |
| SCHEMBL18658903 | 0.82 | LRRK2 (0.73) | LRRK2 | |
| SCHEMBL18634359 | 0.81 | LRRK2 (0.74) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017046675-A1 | NOVEL IMIDAZO [4,5-C] QUINOLINE AND IMIDAZO [4,5-C][1,5] NAPHTHYRIDINE DERIVATIVES AS LRRK2 INHIBITORS | PFIZER INC. (US) | 2017-03-23 | — | — | WO | disclosed |