Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 20/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23922646 | 1.00 | LRRK2 (0.51) | LRRK2 | |
| SCHEMBL18606520 | 1.00 | LRRK2 (0.51) | LRRK2 | |
| SCHEMBL18658918 | 0.85 | LRRK2 (0.65) | LRRK2 | |
| SCHEMBL18606319 | 0.85 | LRRK2 (0.65) | LRRK2 | |
| SCHEMBL18606376 | 0.85 | LRRK2 (0.65) | LRRK2 | |
| SCHEMBL18606402 | 0.81 | LRRK2 (0.76) | LRRK2 | |
| SCHEMBL18606522 | 0.81 | LRRK2 (0.62) | LRRK2 | |
| SCHEMBL18606411 | 0.81 | LRRK2 (0.76) | LRRK2 | |
| SCHEMBL18606415 | 0.81 | LRRK2 (0.62) | LRRK2 | |
| SCHEMBL23934994 | 0.81 | LRRK2 (0.76) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3350178-B1 | NOVEL IMIDAZO [4,5-C]QUINOLINE AND IMIDAZO [4,5-C][1,5]NAPHTHYRIDINE DERIVATIVES AS LRRK2 INHIBITORS | PFIZER (US) | 2021-10-20 | — | — | EP | disclosed |
| WO-2017046675-A1 | NOVEL IMIDAZO [4,5-C] QUINOLINE AND IMIDAZO [4,5-C][1,5] NAPHTHYRIDINE DERIVATIVES AS LRRK2 INHIBITORS | PFIZER INC. (US) | 2017-03-23 | — | — | WO | disclosed |