Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 18/20 | 0.55 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.49 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.49 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.49 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.49 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.49 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.49 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38657376 | 1.00 | MTOR (0.55) | MTORPIK3CAPIK3R1PIK3CGPIK3CD | |
| SCHEMBL1408886 | 0.94 | MTOR (0.56) | MTORPIK3CAPIK3R1PIK3CGPIK3CD | |
| SCHEMBL1408574 | 0.90 | PIK3CA (0.73) | MTORPIK3CAPIK3R1PIK3CGPIK3CD | |
| SCHEMBL1409643 | 0.88 | PIK3CA (0.60) | MTORPIK3CAPIK3R1PIK3CGPIK3CD | |
| SCHEMBL1409935 | 0.86 | PIK3CA (0.58) | MTORPIK3CAPIK3R1PIK3CGPIK3CD | |
| SCHEMBL1409603 | 0.86 | MTOR (0.61) | MTORPIK3CAPIK3R1PIK3CGPIK3CD | |
| SCHEMBL1409605 | 0.86 | MTOR (0.61) | MTORPIK3CAPIK3R1PIK3CGPIK3CD | |
| SCHEMBL1409690 | 0.84 | PIK3CA (0.60) | MTORPIK3CAPIK3R1PIK3CGPIK3CD | |
| SCHEMBL628559 | 0.84 | MTOR (0.51) | MTORPIK3CAPIK3R1PIK3CGPIK3CD | |
| SCHEMBL1409514 | 0.81 | PIK3CA (0.43) | MTORPIK3CAPIK3R1PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3216793-B1 | TRIAZINE COMPOUNDS AS P13 KINASE AND MTOR INHIBITORS | WYETH LLC (US) | 2019-03-27 | — | — | EP | disclosed |
| EP-3216793-A1 | TRIAZINE COMPOUNDS AS P13 KINASE AND MTOR INHIBITORS | Wyeth LLC (US) | 2017-09-13 | — | — | EP | disclosed |
| EP-2294072-B1 | TRIAZINE COMPOUNDS AS P13 KINASE AND MTOR INHIBITORS | WYETH LLC (US) | 2017-03-29 | — | — | EP | disclosed |