Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 16/20 | 0.62 |
| ▸ | TLR7 | Q9NYK1 | 9/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18109529 | 0.84 | TLR8 (0.74) | TLR8TLR7KCNH2 | |
| SCHEMBL18109528 | 0.84 | TLR8 (0.74) | TLR8TLR7KCNH2 | |
| SCHEMBL18109379 | 0.79 | TLR8 (1.00) | TLR8TLR7KCNH2 | |
| SCHEMBL18109380 | 0.79 | TLR8 (1.00) | TLR8TLR7KCNH2 | |
| SCHEMBL18109487 | 0.79 | TLR8 (1.00) | TLR8TLR7KCNH2 | |
| SCHEMBL18109664 | 0.78 | TLR8 (1.00) | TLR8TLR7KCNH2 | |
| SCHEMBL18109661 | 0.78 | TLR8 (1.00) | TLR8TLR7KCNH2 | |
| SCHEMBL19940711 | 0.76 | KCNH2 (0.52) | TLR8TLR7KCNH2 | |
| SCHEMBL19991824 | 0.76 | KCNH2 (0.52) | TLR8TLR7KCNH2 | |
| SCHEMBL18124727 | 0.74 | TLR8 (1.00) | TLR8TLR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017048727-A1 | MODULATORS OF TOLL-LIKE RECPTORS FOR THE TREATMENT OF HIV | GILEAD SCIENCES, INC. (US) | 2017-03-23 | — | — | WO | disclosed |