Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.43 |
| ▸ | LCAT | P04180 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18664830 | 0.86 | CHRNB4 (0.36) | HRH3LCATMAP4K4HPGDSCHRNB2 | |
| SCHEMBL15859901 | 0.81 | CDK1 (0.45) | HRH3CDK1MEN1KMT2AHRH4 | |
| SCHEMBL784764 | 0.81 | LCAT (0.41) | LCATHPGDSHRH4 | |
| SCHEMBL16769754 | 0.78 | LCAT (0.45) | HRH3LCATMEN1KMT2AHPGDS | |
| SCHEMBL16648684 | 0.78 | MAPT (0.56) | MEN1KMT2AMAPT | |
| SCHEMBL27902608 | 0.78 | LCAT (0.38) | HRH3LCATCHRNB2CHRNA4MAPT | |
| SCHEMBL18664911 | 0.78 | HRH3 (0.57) | HRH3CDK1MEN1KMT2AMAPT | |
| SCHEMBL23515063 | 0.75 | NPC1 (0.43) | LCATMAP4K4MEN1KMT2AMAPT | |
| SCHEMBL23515151 | 0.74 | DOT1L (0.41) | LCATMAP4K4HRH4 | |
| SCHEMBL25085543 | 0.74 | HRH3 (0.39) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017049173-A1 | FARNESOID X RECEPTOR AGONISTS AND USES THEREOF | METACRINE, INC. (US) | 2017-03-23 | — | — | WO | disclosed |