Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 6/20 | 0.47 |
| ▸ | CDK1 | P06493 | 3/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | MGMT | P16455 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24383709 | 0.85 | HSP90AB1 (0.51) | HSP90AA1HSP90AB1CDK1CCNB1CCNE1 | |
| SCHEMBL23346497 | 0.83 | MGMT (0.49) | HSP90AA1HSP90AB1CDK1MGMTCYP2C19 | |
| SCHEMBL17622515 | 0.82 | HSP90AB1 (0.48) | HSP90AA1HSP90AB1CDK1CCNB1CCNE1 | |
| SCHEMBL1567494 | 0.81 | FGFR1 (0.60) | HSP90AA1HSP90AB1POLBFGFR1SLC22A6 | |
| SCHEMBL30824623 | 0.81 | FGFR1 (0.60) | HSP90AA1HSP90AB1POLBFGFR1SLC22A6 | |
| SCHEMBL17625419 | 0.81 | HSP90AB1 (0.46) | HSP90AA1HSP90AB1CDK1CCNB1CCNE1 | |
| SCHEMBL29193218 | 0.81 | HSP90AB1 (0.52) | HSP90AA1HSP90AB1CDK1CCNB1CCNE1 | |
| SCHEMBL17617663 | 0.81 | POLB (0.51) | HSP90AA1HSP90AB1CDK1CCNB1CCNE1 | |
| SCHEMBL17608710 | 0.80 | HSP90AB1 (0.44) | HSP90AA1HSP90AB1CDK1CCNB1CCNE1 | |
| SCHEMBL17608708 | 0.79 | HSP90AB1 (0.46) | HSP90AA1HSP90AB1CDK1CCNB1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017048956-A1 | NUCLEOTIDE ANALOGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-03-23 | — | — | WO | disclosed |