Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 10/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.52 |
| ▸ | P2RY12 | Q9H244 | 5/20 | 0.51 |
| ▸ | PRKDC | P78527 | 5/20 | 0.51 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1872818 | 0.91 | PIK3CB (0.53) | PIK3CBPIK3CDPIK3CAPIK3CGP2RY12 | |
| SCHEMBL1871780 | 0.86 | PIK3CB (0.69) | PIK3CBPIK3CDPIK3CAPIK3CGPRKDC | |
| Bromide SCHEMBL1868104 | 0.85 | PIK3CB (0.68) | PIK3CBPIK3CDPIK3CAPIK3CGPRKDC | |
| SCHEMBL1638322 | 0.84 | PRKDC (0.55) | PIK3CBPIK3CDPIK3CAPIK3CGP2RY12 | |
| SCHEMBL1863568 | 0.84 | PIK3CB (0.56) | PIK3CBPIK3CDPIK3CAPIK3CG | |
| Bromide SCHEMBL1868689 | 0.83 | PIK3CB (0.55) | PIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL1870485 | 0.82 | PIK3CB (0.63) | PIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL1639250 | 0.82 | PRKDC (0.55) | PIK3CBPIK3CDPIK3CAPIK3CGP2RY12 | |
| SCHEMBL12666449 | 0.82 | PRKDC (0.55) | PIK3CBPIK3CDPIK3CAPIK3CGP2RY12 | |
| SCHEMBL1873837 | 0.82 | PIK3CB (0.69) | PIK3CBPIK3CDPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493870-A1 | CHROMENONE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | AstraZeneca AB (SE) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011051704-A1 | CHROMENONE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | ASTRAZENECA AB (SE) | 2011-05-05 | — | — | WO | disclosed |