Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18667754 | 0.91 | KMT2A (0.49) | TP53MAPTSMN1; SMN2HPGDKMT2A | |
| SCHEMBL18667456 | 0.91 | TP53 (0.49) | TP53MAPTSMN1; SMN2HPGDKMT2A | |
| SCHEMBL18667663 | 0.89 | TP53 (0.49) | TP53MAPTSMN1; SMN2HPGDKMT2A | |
| SCHEMBL18667667 | 0.89 | HPGD (0.49) | TP53MAPTSMN1; SMN2HPGDKMT2A | |
| SCHEMBL18667344 | 0.88 | HPGD (0.49) | TP53MAPTSMN1; SMN2HPGDKMT2A | |
| SCHEMBL17086084 | 0.88 | HPGD (0.53) | TP53MAPTSMN1; SMN2HPGDKMT2A | |
| SCHEMBL18667668 | 0.88 | TP53 (0.49) | TP53MAPTSMN1; SMN2HPGDKMT2A | |
| SCHEMBL18667437 | 0.87 | HPGD (0.51) | TP53MAPTSMN1; SMN2HPGDKMT2A | |
| SCHEMBL30271094 | 0.87 | HPGD (0.51) | TP53MAPTSMN1; SMN2HPGDKMT2A | |
| SCHEMBL18667205 | 0.87 | HPGD (0.51) | TP53MAPTSMN1; SMN2HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3782626-A1 | HEPATITIS B CORE PROTEIN MODULATORS | Assembly Biosciences, Inc. (US) | 2021-02-24 | — | — | EP | disclosed |
| WO-2017048950-A1 | HEPATITIS B CORE PROTEIN MODULATORS | ASSEMBLY BIOSCIENCES, INC. (US) | 2017-03-23 | — | — | WO | disclosed |