Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 15/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.30 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.30 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.30 |
| ▸ | LDHA | P00338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1866468 | 0.86 | ADORA1 (0.42) | ADORA1ADORA3ADORA2BADORA2A | |
| SCHEMBL1871458 | 0.85 | ADORA1 (0.43) | ADORA1ADORA3ADORA2BADORA2APTGER2 | |
| SCHEMBL1867558 | 0.81 | ADORA1 (0.54) | ADORA1ADORA3ADORA2BADORA2ASLC6A3 | |
| SCHEMBL18059635 | 0.80 | ADORA1 (0.42) | ADORA1ADORA3ADORA2BADORA2A | |
| SCHEMBL12080727 | 0.76 | ADORA1 (0.54) | ADORA1ADORA3ADORA2BADORA2ASLC6A3 | |
| SCHEMBL18059631 | 0.75 | ADORA1 (0.44) | ADORA1ADORA3ADORA2BADORA2ASLC6A3 | |
| SCHEMBL1870633 | 0.75 | ADORA1 (0.53) | ADORA1ADORA3ADORA2BADORA2A | |
| SCHEMBL18059621 | 0.74 | ADORA1 (0.49) | ADORA1ADORA3ADORA2BADORA2A | |
| SCHEMBL1874864 | 0.72 | ADORA1 (0.54) | ADORA1ADORA3ADORA2BADORA2ASLC6A3 | |
| SCHEMBL12089679 | 0.72 | ADORA1 (0.52) | ADORA1ADORA3ADORA2BADORA2ASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499142-A1 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS, ITS PREPARATION AND USES THEREOF | Advinus Therapeutics Limited (IN) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011055391-A1 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS, ITS PREPARATION AND USES THEREOF | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2011-05-12 | — | — | WO | disclosed |