Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN7 | P35236 | 5/20 | 0.52 |
| ▸ | HMGCR | P04035 | 5/20 | 0.52 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SELP | P16109 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4845876 | 0.96 | PTPN7 (0.50) | PTPN7HMGCRRECQLTDP1EPHX2 | |
| SCHEMBL31317692 | 0.96 | PTPN7 (0.50) | PTPN7HMGCRRECQLTDP1EPHX2 | |
| SCHEMBL272763 | 0.96 | PTPN7 (0.50) | PTPN7HMGCRRECQLTDP1EPHX2 | |
| SCHEMBL3503759 | 0.96 | PTPN7 (0.50) | PTPN7HMGCRRECQLTDP1EPHX2 | |
| SCHEMBL28249427 | 0.96 | PTPN7 (0.50) | PTPN7HMGCRRECQLTDP1EPHX2 | |
| SCHEMBL9336107 | 0.96 | PTPN7 (0.50) | PTPN7HMGCRRECQLTDP1EPHX2 | |
| SCHEMBL28336578 | 0.96 | PTPN7 (0.50) | PTPN7HMGCRRECQLTDP1EPHX2 | |
| SCHEMBL28250106 | 0.94 | PTPN7 (0.48) | PTPN7HMGCRRECQLTDP1EPHX2 | |
| SCHEMBL158657 | 0.94 | PTPN7 (0.47) | PTPN7HMGCRRECQLTDP1EPHX2 | |
| SCHEMBL28200583 | 0.94 | PTPN7 (0.47) | PTPN7HMGCRRECQLTDP1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496682-A1 | DELIVERY PARTICLE | The Procter & Gamble Company (US) | 2012-09-12 | — | — | EP | disclosed |
| WO-2011056935-A1 | DELIVERY PARTICLE | THE PROCTER & GAMBLE COMPANY (US) | 2011-05-12 | — | — | WO | disclosed |