Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 12/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | SMO | Q99835 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18670956 | 0.86 | HDAC1 (0.57) | HDAC2HDAC1HDAC3MAPK14SMO | |
| SCHEMBL18670953 | 0.84 | HDAC1 (0.65) | HDAC2HDAC1HDAC3MAPK14SMO | |
| SCHEMBL4578851 | 0.84 | HDAC2 (0.73) | HDAC2HDAC1HDAC3MAPK14SMO | |
| SCHEMBL18653509 | 0.83 | HDAC2 (0.75) | HDAC2HDAC1HDAC3 | |
| SCHEMBL31109060 | 0.83 | HDAC2 (0.56) | HDAC2HDAC1HDAC3MAPK14SMO | |
| SCHEMBL18670957 | 0.83 | HDAC1 (0.55) | HDAC2HDAC1HDAC3MAPK14SMO | |
| SCHEMBL25216137 | 0.82 | HDAC2 (0.57) | HDAC2HDAC1HDAC3MAPK14SMO | |
| SCHEMBL18670966 | 0.82 | HDAC1 (0.73) | HDAC2HDAC1HDAC3MAPK14SMO | |
| SCHEMBL14082258 | 0.81 | TRPV1 (0.71) | TP53 | |
| SCHEMBL18670977 | 0.80 | HDAC1 (0.65) | HDAC2HDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9603950-B1 | Compounds of imaging agent with HDAC inhibitor for treatment of Alzheimer syndrome and method of synthesis thereof | INSTITUTE OF NUCLEAR ENERGY RESEARCH (TW) | 2017-03-28 | — | — | US | disclosed |
| US-9603950-B1 | Compounds of imaging agent with HDAC inhibitor for treatment of Alzheimer syndrome and method of synthesis thereof | INSTITUTE OF NUCLEAR ENERGY RESEARCH (TW) | 2017-03-28 | — | — | US | disclosed |