Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | DDR2 | Q16832 | 8/20 | 0.35 |
| ▸ | ITK | Q08881 | 3/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 4/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1867129 | 1.00 | GSK3B (0.35) | GSK3BDYRK1ADDR2ITKEGFR | |
| SCHEMBL1573258 | 0.92 | GSK3B (0.35) | GSK3BDYRK1ADDR2ITKEGFR | |
| SCHEMBL1573257 | 0.92 | GSK3B (0.35) | GSK3BDYRK1ADDR2ITKEGFR | |
| SCHEMBL1572431 | 0.91 | GSK3B (0.37) | GSK3BDYRK1ADDR2ITKEGFR | |
| SCHEMBL1572430 | 0.91 | GSK3B (0.37) | GSK3BDYRK1ADDR2ITKEGFR | |
| SCHEMBL1571351 | 0.84 | GSK3B (0.39) | GSK3BDYRK1ADDR2ITKEGFR | |
| SCHEMBL3504727 | 0.82 | BRAF (0.37) | DDR2EGFRBRAFRAF1 | |
| SCHEMBL1572814 | 0.80 | GSK3B (0.38) | GSK3BDYRK1ADDR2 | |
| SCHEMBL1571672 | 0.80 | GSK3B (0.38) | GSK3BDYRK1ADDR2 | |
| SCHEMBL1572812 | 0.80 | GSK3B (0.38) | GSK3BDYRK1ADDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079988-A9 | QUINAZOLINES FOR PDK1 INHIBITION | NOVARTIS AG (CH) | 2011-05-12 | — | — | WO | disclosed |