Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 12/20 | 0.71 |
| ▸ | MMEL1 | Q495T6 | 9/20 | 0.71 |
| ▸ | ACE | P12821 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12317267 | 1.00 | MME (0.71) | MMEMMEL1ACE | |
| SCHEMBL12317268 | 0.93 | MME (0.69) | MMEMMEL1ACE | |
| SCHEMBL18672592 | 0.93 | MME (0.69) | MMEMMEL1ACE | |
| SCHEMBL18672626 | 0.89 | MME (0.76) | MMEMMEL1ACE | |
| SCHEMBL12317265 | 0.89 | MME (0.76) | MMEMMEL1ACE | |
| SCHEMBL18672588 | 0.85 | MME (0.78) | MMEMMEL1ACE | |
| SCHEMBL12317251 | 0.85 | MME (0.78) | MMEMMEL1ACE | |
| SCHEMBL12317370 | 0.84 | MME (0.57) | MMEMMEL1ACE | |
| SCHEMBL18672710 | 0.84 | MME (0.57) | MMEMMEL1ACE | |
| SCHEMBL2705969 | 0.84 | MME (1.00) | MMEMMEL1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9603819-B2 | Substituted aminobutyric derivatives as neprilysin inhibitors | NOVARTIS AG (CH) | 2017-03-28 | — | — | US | disclosed |