Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 13/20 | 0.71 |
| ▸ | MMEL1 | Q495T6 | 7/20 | 0.71 |
| ▸ | ACE | P12821 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2707400 | 1.00 | MME (0.71) | MMEMMEL1ACE | |
| SCHEMBL16821239 | 1.00 | MME (0.71) | MMEMMEL1ACE | |
| SCHEMBL18672859 | 0.90 | MME (0.72) | MMEMMEL1ACE | |
| SCHEMBL2705199 | 0.90 | MME (0.72) | MMEMMEL1ACE | |
| SCHEMBL8577902 | 0.89 | MME (0.76) | MMEMMEL1ACE | |
| SCHEMBL18672635 | 0.89 | MME (0.76) | MMEMMEL1ACE | |
| SCHEMBL12939468 | 0.86 | MME (0.71) | MMEMMEL1ACE | |
| SCHEMBL2705846 | 0.85 | MME (0.55) | MMEMMEL1ACE | |
| SCHEMBL3760280 | 0.85 | MME (0.55) | MMEMMEL1ACE | |
| SCHEMBL10197967 | 0.83 | MME (1.00) | MMEMMEL1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9603819-B2 | Substituted aminobutyric derivatives as neprilysin inhibitors | NOVARTIS AG (CH) | 2017-03-28 | — | — | US | disclosed |