Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.56 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.56 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.51 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1868748 | 0.84 | GRM4 (0.65) | AKR1C3AKR1C2AKR1C1CYP3A4KDM4E | |
| SCHEMBL1875055 | 0.83 | GRM4 (0.76) | GRM4 | |
| SCHEMBL13558515 | 0.83 | GRM4 (0.76) | GRM4 | |
| SCHEMBL1875054 | 0.83 | GRM4 (0.76) | GRM4 | |
| SCHEMBL1868837 | 0.82 | HPGD (0.56) | CYP3A4KDM4EHPGDMEN1MAPT | |
| SCHEMBL312714 | 0.78 | TNKS (0.62) | AKR1C3AKR1C2AKR1C1CYP3A4KDM4E | |
| SCHEMBL1866238 | 0.77 | GRM4 (0.54) | GRM4 | |
| Flavone SCHEMBL28494355 | 0.76 | TNKS (0.72) | AKR1C3AKR1C2AKR1C1CYP3A4KDM4E | |
| SCHEMBL1870119 | 0.76 | MAPT (0.59) | CYP3A4KDM4EHPGDMEN1MAPT | |
| SCHEMBL15988177 | 0.75 | TNKS (0.56) | CYP3A4KDM4EHPGDMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493871-A1 | NOVEL OXIME DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Domain Therapeutics (FR) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011051478-A1 | NOVEL OXIME DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | DOMAIN THERAPEUTICS (FR) | 2011-05-05 | — | — | WO | disclosed |