SCHEMBL18682153

SCHEMBL18682153

CC(=O)c1ccc2c(c1)C1c3cc(C(C)=O)ccc3C2c2ccc(C(C)=O)cc21

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA1 P02708 1/20 0.53
CHRNG P07510 1/20 0.53
CHRNB1 P11230 1/20 0.53
CHRNB2 P17787 1/20 0.53
CHRNB4 P30926 1/20 0.53
CHRNA3 P32297 1/20 0.53
CHRNA4 P43681 1/20 0.53
CHRND Q07001 1/20 0.53
NOS3 P29474 2/20 0.47
NOS1 P29475 2/20 0.47
PRKCI P41743 1/20 0.46
MAPT P10636 5/20 0.45
RAB9A P51151 4/20 0.45
NPC1 O15118 3/20 0.45
CYP2A6 P11509 1/20 0.44
PKM P14618 1/20 0.42
CREBBP Q92793 1/20 0.42
HPGD P15428 3/20 0.41
LMNA P02545 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15180320 0.80 CHRNA1 (0.51) CHRNA1CHRNGCHRNB1CHRNB2CHRNB4
SCHEMBL13563804 0.80 CHRNA1 (0.51) CHRNA1CHRNGCHRNB1CHRNB2CHRNB4
SCHEMBL18682217 0.79 TSHR (0.50) MAPTHPGDL3MBTL1KMT2AALDH1A1
SCHEMBL18670700 0.79 TSHR (0.50) MAPTHPGDL3MBTL1KMT2AALDH1A1
SCHEMBL18682115 0.77 CA1 (0.55) CHRNB2CHRNA4MAPTRAB9AHPGD
SCHEMBL11115696 0.77 CHRNA1 (0.53) CHRNA1CHRNGCHRNB1CHRNB2CHRNB4
SCHEMBL10170777 0.77 CHRNA1 (0.53) CHRNA1CHRNGCHRNB1CHRNB2CHRNB4
SCHEMBL15180321 0.75 CHRNA1 (0.47) CHRNA1CHRNGCHRNB1CHRNB2CHRNB4
SCHEMBL13563809 0.75 CHRNA1 (0.47) CHRNA1CHRNGCHRNB1CHRNB2CHRNB4
SCHEMBL12620636 0.75 CHRNA1 (0.51) CHRNA1CHRNGCHRNB1CHRNB2CHRNB4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017053982-A1 TRIPTYCENE DERIVATIVES FOR NUCLEIC ACID JUNCTION STABILIZATION THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2017-03-30 WO disclosed