Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 17/20 | 0.73 |
| ▸ | JAK2 | O60674 | 13/20 | 0.73 |
| ▸ | TYK2 | P29597 | 1/20 | 0.71 |
| ▸ | JAK3 | P52333 | 1/20 | 0.71 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18685131 | 0.91 | JAK1 (0.72) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL18668732 | 0.87 | JAK1 (0.79) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL18662642 | 0.87 | JAK1 (0.79) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL25407580 | 0.86 | JAK1 (0.74) | JAK1JAK2 | |
| SCHEMBL18662664 | 0.85 | JAK1 (1.00) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL29392641 | 0.85 | JAK1 (1.00) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL29466940 | 0.85 | JAK1 (1.00) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL29394460 | 0.85 | JAK1 (1.00) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL18662598 | 0.85 | JAK1 (1.00) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL18662584 | 0.85 | JAK1 (1.00) | JAK1JAK2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219482-A1 | COMPOUNDS AND METHODS FOR INHIBITING JAK | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2023-08-02 | — | — | EP | disclosed |
| WO-2017050938-A1 | COMPOUNDS AND METHODS FOR INHIBITING JAK | ASTRAZENECA AB (SE) | 2017-03-30 | — | — | WO | disclosed |