Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18685091 | 0.91 | KDM4A (0.48) | KDM4APOLBMAPK1ATMCTSS | |
| SCHEMBL25306120 | 0.86 | KDM4A (0.44) | KDM4APOLBMAPK1ATMCTSS | |
| SCHEMBL29473242 | 0.84 | KDM4A (0.43) | KDM4APOLBMAPK1ATMCTSS | |
| SCHEMBL21987975 | 0.84 | HDAC1 (0.46) | KDM4APOLBMAPK1ATMCTSS | |
| SCHEMBL29473241 | 0.84 | KDM4A (0.43) | KDM4APOLBMAPK1ATMCTSS | |
| SCHEMBL29076001 | 0.84 | POLB (0.44) | KDM4APOLBMAPK1ATMCTSS | |
| SCHEMBL3127618 | 0.84 | KDM4A (0.43) | KDM4APOLBMAPK1ATMCTSS | |
| SCHEMBL25366785 | 0.84 | POLB (0.41) | KDM4APOLBMAPK1ATMCTSS | |
| SCHEMBL21135383 | 0.83 | POLB (0.49) | KDM4APOLBMAPK1ATMSCN9A | |
| SCHEMBL29592899 | 0.83 | POLB (0.49) | KDM4APOLBMAPK1ATMSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2961745-B1 | PHENYLPYRAZOLE DERIVATIVES AS POTENT ROCK1 AND ROCK2 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-03-29 | — | — | EP | disclosed |