Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 18/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18685466 | 0.91 | PDE10A (0.77) | PDE10ANAMPT | |
| SCHEMBL14812419 | 0.87 | PDE10A (0.84) | PDE10A | |
| SCHEMBL14812398 | 0.83 | PDE10A (1.00) | PDE10A | |
| SCHEMBL14811995 | 0.83 | PDE10A (1.00) | PDE10A | |
| SCHEMBL14811495 | 0.83 | PDE10A (0.71) | PDE10A | |
| SCHEMBL14821977 | 0.81 | PDE10A (1.00) | PDE10A | |
| SCHEMBL14812249 | 0.81 | PDE10A (1.00) | PDE10A | |
| SCHEMBL18685445 | 0.79 | PDE10A (0.71) | PDE10A | |
| SCHEMBL18685476 | 0.79 | PDE10A (0.68) | PDE10A | |
| SCHEMBL14811781 | 0.78 | PDE10A (1.00) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2758396-B1 | TRIAZOLOPYRIDINE COMPOUNDS AS PDE10A INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-03-29 | — | — | EP | disclosed |