Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 19/20 | 0.75 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.56 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.56 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.56 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.56 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.56 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.56 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.56 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18686219 | 0.96 | CFTR (0.72) | CFTRMAOBGABRA1GABRB1GABRA5 | |
| SCHEMBL18686226 | 0.94 | CFTR (0.77) | CFTRMAOBGABRA1GABRB1GABRA5 | |
| SCHEMBL397792 | 0.91 | CFTR (0.70) | CFTRMAOBGABRA1GABRB1GABRA5 | |
| SCHEMBL398603 | 0.90 | CFTR (0.72) | CFTRMAOBGABRA1GABRB1GABRA5 | |
| SCHEMBL397397 | 0.90 | CFTR (0.72) | CFTRMAOBGABRA1GABRB1GABRA5 | |
| SCHEMBL18686214 | 0.90 | CFTR (0.73) | CFTRMAOBGABRA1GABRB1GABRA5 | |
| SCHEMBL399212 | 0.89 | CFTR (0.70) | CFTRMAOBGABRA1GABRB1GABRA5 | |
| SCHEMBL396591 | 0.88 | CFTR (0.69) | CFTRMAOBGABRA1GABRB1GABRA5 | |
| SCHEMBL397525 | 0.87 | CFTR (0.71) | CFTRMAOBGABRA1GABRB1GABRA5 | |
| SCHEMBL399222 | 0.87 | CFTR (0.75) | CFTRMAOBGABRA1GABRB1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2502911-B1 | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2017-04-05 | — | — | EP | claimed |