Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SETDB1 | Q15047 | 1/20 | 0.40 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 6/20 | 0.34 |
| ▸ | BRD2 | P25440 | 6/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 6/20 | 0.34 |
| ▸ | CCKBR | P32239 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11854726 | 0.59 | BRD4 (0.40) | SETDB1BRD4 | |
| SCHEMBL4398893 | 0.59 | MYC (0.51) | SETDB1BRD4BRD2BRD3 | |
| Hydrochloric Acid SCHEMBL7208149 | 0.57 | CHEK1 (0.36) | BRD4 | |
| SCHEMBL19292768 | 0.57 | SETDB1 (0.50) | SETDB1BRD4 | |
| SCHEMBL4409807 | 0.56 | MYC (0.51) | AVPR2AVPR1A | |
| SCHEMBL15573654 | 0.56 | KCNH2 (0.39) | — | |
| SCHEMBL10480847 | 0.55 | AVPR1A (0.66) | AVPR1A | |
| SCHEMBL3421771 | 0.54 | AVPR1A (0.67) | AVPR1A | |
| SCHEMBL5832812 | 0.53 | AVPR1A (0.64) | AVPR2AVPR1A | |
| SCHEMBL3255696 | 0.51 | ELANE (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496581-A1 | CONDENSED AZEPINE DERIVATIVES AS BROMODOMAIN INHIBITORS | GlaxoSmithKline LLC (US) | 2012-09-12 | — | — | EP | claimed |
| WO-2011054844-A1 | CONDENSED AZEPINE DERIVATIVES AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | claimed |