Enprostil

Enprostil

SCHEMBL186877

COC(=O)CCC=C=CC[C@H]1C(=O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)COc1ccccc1

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PTGFR P43088 13/20 0.64
PTGER3 P43115 12/20 0.64
MEN1 O00255 1/20 0.61
THRB P10828 1/20 0.61
KMT2A Q03164 1/20 0.61
TBXA2R P21731 2/20 0.46
PTGER1 P34995 2/20 0.46
PTGIR P43119 5/20 0.43
MGLL Q99685 1/20 0.43
PTGER4 P35408 3/20 0.42
PTGER2 P43116 3/20 0.42
NR1I2 O75469 1/20 0.41
ESR1 P03372 1/20 0.41
PGR P06401 1/20 0.41
HPGD P15428 1/20 0.41
TSHR P16473 1/20 0.41
MAPK1 P28482 1/20 0.41
OPRK1 P41145 1/20 0.41
PDE4D Q08499 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Enprostil SCHEMBL10746954 1.00 PTGFR (0.64) PTGFRPTGER3MEN1THRBKMT2A
Enprostil SCHEMBL10746961 1.00 PTGFR (0.64) PTGFRPTGER3MEN1THRBKMT2A
Enprostil SCHEMBL7107661 1.00 PTGFR (0.64) PTGFRPTGER3MEN1THRBKMT2A
Enprostil SCHEMBL1650019 1.00 PTGFR (0.64) PTGFRPTGER3MEN1THRBKMT2A
SCHEMBL10780690 0.91 PTGFR (0.74) PTGFRPTGER3MEN1THRBKMT2A
SCHEMBL11021383 0.91 PTGFR (0.74) PTGFRPTGER3MEN1THRBKMT2A
SCHEMBL11101989 0.91 PTGFR (0.74) PTGFRPTGER3MEN1THRBKMT2A
SCHEMBL11021375 0.91 PTGFR (0.74) PTGFRPTGER3MEN1THRBKMT2A
SCHEMBL24340818 0.89 PTGFR (0.77) PTGFRPTGER3MEN1THRBKMT2A
SCHEMBL11891872 0.89 PTGFR (0.77) PTGFRPTGER3MEN1THRBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2047 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12569437-B2 Disease-site-specific liposomal formulation OSAKA UNIVERSITY (JP) 2026-03-10 US claimed
EP-3895686-B1 NATURAL COMPOSITION FOR HAIR GROWTH STIMULATION AND HAIR LOSS PREVENTION AND TREATMENT FRAUNHOFER GES FORSCHUNG (DE) 2025-04-09 EP claimed
CN-118453877-A Application of small molecular compound combination in preparing medicine for starting liver in-situ regeneration 中国人民解放军海军军医大学 2024-08-09 CN claimed
US-20240082154-A1 DISEASE-SITE-SPECIFIC LIPOSOMAL FORMULATION CUORIPS INC. (JP) 2024-03-14 US claimed
CN-117018195-A Application of small molecular compound or combination in preparation of medicine for starting liver in-situ regeneration 中国人民解放军海军军医大学 2023-11-10 CN claimed
WO-2021209442-A1 NATURAL COMPOSITION FOR HAIR GROWTH STIMULATION AND HAIR LOSS PREVENTION AND TREATMENT Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V. (DE) 2021-10-21 WO claimed
WO-2021209437-A1 NATURAL COMPOSITION FOR HAIR GROWTH STIMULATION AND HAIR LOSS PREVENTION AND TREATMENT WITHOUT PRESERVATIVES Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V. (DE) 2021-10-21 WO claimed
EP-3895685-A1 NATURAL COMPOSITION FOR HAIR GROWTH STIMULATION AND HAIR LOSS PREVENTION AND TREATMENT WITHOUT PRESERVATIVES Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (DE) 2021-10-20 EP claimed
EP-3895686-A1 NATURAL COMPOSITION FOR HAIR GROWTH STIMULATION AND HAIR LOSS PREVENTION AND TREATMENT FRAUNHOFER-GESELLSCHAFT zur Förderung der angewandten Forschung e.V. (DE) 2021-10-20 EP claimed
EP-3810184-A2 METHODS OF TREATING OR INHIBITING ONSET OF HUNTINGTON'S DISEASE University of Rochester (US) 2021-04-28 EP claimed
CN-1080168-A The preparation method of the Entogastric lingering slow releasing preparation of treatment digestive ulcer medicament CONG FANZI (CN) 1994-01-05 CN claimed
WO-1992006684-A1 A NEW USE OF ENPROSTIL SYNTEX (USA) INC. (US) 1992-04-30 WO claimed
EP-0248999-A2 Uses of enprostil-type prostaglandins in regulating fat and carbohydrate metabolism SYNTEX (U.S.A.) INC. (US) 1987-12-16 EP claimed
EP-0186181-A3 USES FOR ENPROSTIL SYNTEX (U.S.A.) INC. (US) 1986-08-13 EP claimed
EP-0186181-A2 Uses for enprostil SYNTEX (U.S.A.) INC. (US) 1986-07-02 EP claimed
EP-0058418-B1 CARBONATE DIESTER SOLUTIONS OF PGE-TYPE COMPOUNDS SYNTEX (U.S.A.) INC. (US) 1986-05-28 EP claimed
US-4410545-A PROSTAGLANDINS CONTAINING AN ALLENE GROUP SYNTEX (U.S.A.) INC. (US) 1983-10-18 US claimed
US-4409239-A ENCAPSULATION SYNTEX (U.S.A.) INC. (US) 1983-10-11 US claimed
EP-0084865-A1 Propylene glycol diester solutions of PGE-type compounds SYNTEX (U.S.A.) INC. (US) 1983-08-03 EP claimed
EP-0008003-A1 (dl)-16-Phenoxy- and 16-substituted phenoxy-9-keto prostatrienoic acids and derivatives and processes for the production thereof and their pharmaceutical compositions SYNTEX (U.S.A.) INC. (US) 1980-02-20 EP claimed